Get a colonoscopy, because this exam is the best way to check for colorectal cancer—a disease that affects a large number of American men and many women, too. The screening looks for abnormalities in the lower part of your digestive system, because sometimes there are no visible symptoms in the early stages of the disease. The good news is that colorectal cancer is highly detectable, and it’s easier to treat when caught early. So, make a plan to get screened if you’re due.